PATH 3610 Lecture Notes - Lecture 8: Wound Healing, Granulation Tissue, Granuloma
14 May 2018
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Healing: Tissue Renewal and repair
- Regenerate or repair: basic steps
o Agent inactivated and removed
o Debride nonviable materials – uses macrophages for this
o Provide building framework – by growing blood vessels and cells that
replace existing tissues
▪ Angiogenesis – getting blood, fluids, nutrition
▪ Migration of cells – for healing process
▪ Proliferation – grow and produce lots of other cells
o Regenerate or repair!
o You get scars because you cant regenerate
- Repair: Granulation tissue
o Fundamental repair system in tissue that cannot regenerate (scar
formation)
▪ Scar tissue happens when you cant regenerate
o Fibrous tissue → fibroblasts and matrix/collagen
▪ Fibroblasts and blood vessels together → granulomous tissue
o Capillaries
o NOT granulomatous inflammation
- Repair: Wound healing by
o First intention
▪ 24 hours – neutrophils
▪ 3 days – macrophages
▪ 5 days – granulation tissue
▪ 10 days – mature collagen
▪ 1 month – scar
▪ The smaller the wound, the faster it will
heal
▪ The less granulation tissue, the lesser the scar
o Second intention – when you cant close the wound an dits left open
▪ Large tissue defect
• Granulation (lots of granulation tissue develops) –
proud flesh and keloid
• Takes months to heal
o Epidermis (first layer)
▪ Epithelium: very thin, labile cell type (can regenerate and
doesn’t scar)
o Dermis:
▪ Mostly collagen and some elastic fibres
▪ Stable cell type → can replace itself to an extent by scarring
o Subcutis
▪ Fat
o Ex. you cut yourself
▪ Granulation tissue grows from around the dermis and
overtime (5-10) days and gradually changes to scar tissue
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