PATH 3610 Lecture Notes - Lecture 7: Hypercalcaemia, Melanocyte, Peritoneum

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Both are reversible if the demand is removed, tissues will return to normal: hypertrophy and hyperplasia can also occur together, leading to organ enlargement (e. g. physiologic enlargement of the pregnant uterus), hyperplasia and hypertrophy can also be pathologic, occurring without an increased functional demand. Oncogenes can code for: growth factors (i. e. the cancer cell can synthesize the same growth factors to which it responds, growth factor receptors, there may be over expression of growth factor receptors, so cells are hyper responsive to normal levels of growth factor, mutant growth factor receptor proteins can deliver continuous signals for growth, signal transducing proteins, these proteins transfer information from growth factor receptors to their nuclear targets; mutated versions of these signalling proteins (e. g. ras) lead to continuous signals for proliferation, nuclear transcription factors, mutation of genes that regulate dna transcription can lead to continous proliferation, cyclins and cyclin dependent kinases o.

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