PATH 3610 Lecture Notes - Lecture 3: Fibroblast, Acetyl Group, Mycobacterium
7 Aug 2016
School
Department
Course
Professor
Document Summary
Acute inflammation is characterized by the active emigration of inflammatory cells from the blood into the area of tissue injury. Also known as white blood cells or leukocytes. Derived from myeloid cell line w/n bone marrow. Myeloid cell line has two arms, mononuclear cells and granylocytes. Mononuclear cells have smoothly outlined, rounded nucleus. Granulocytes have multilobulated nucleus, contain cytoplasmic granules also called polymorphonuclear leukocytes. Bone marrow = site of differentiation for most leukocytes, red blood cells and platelets. Many bone marrow-derived cells are derived from common precursors. Cell lineages respond to a bunch of different cytokines, colony-stimulating factors and hormones to up or downregulate production of mature forms. Neutrophil = most important/greatest role in acute inflammation. Is the white blood cell seen in greatest numbers in the early stages of inflamation. Actively motile, capable of phagocytosis and contain enzymes which can degrade biologic material.
