ANP 1107 Lecture Notes - Lecture 12: Granulocyte, B Cell, Thymus

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

Ch 17 p 644-649 & ch 21 p 771-799. Leukocytes: only formed elements that are complete cells that protect against bacteria, viruses, parasites, toxins, tumor cells; <1% of total blood volume, usually 4000-11 000 wbcs/microliter. Can leave bloodstream (diapedesis) to mount immune and/or inflammatory response: amoeboid motion and chemotaxis motility. Granulocytes spheri(cid:272)al, larger tha(cid:374) rbcs, lo(cid:271)ed (cid:374)u(cid:272)lei, (cid:272)ytoplas(cid:373)i(cid:272) gra(cid:374)ules; wright"s stai(cid:374: neutrophils: > 50% leukocytes, cytoplasm contains 2 types of granules that take up both acidic and basic dyes. Granules contain hydrolytic enzymes and some antibiotic-like proteins (defensins) = polymorphic leukocytes. Phagocytes ingest and destroy bacteria; i. e meningitis, appendicitis: eosinophils: 2-4% all leukocytes; blue-red coarse nucleus that looks like telephone receiver, red granules. Phagocytic in chronic infections (i. e tb); also against viruses, some bacteria. Leukocyte pathway leukopoiesis (cid:894)produ(cid:272)tio(cid:374)(cid:895) is hor(cid:373)o(cid:374)ally regulated a(cid:272)(cid:272)ordi(cid:374)g to (cid:271)ody"s situatio(cid:374); interleukins and colony stimulating factors are hormones that regulated production of leukocytes as needed.