POPM 4040 Lecture 15: POPM 4040 Lecture : Shigella
22 Dec 2018
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Document Summary
Shigellosis: incidence: worldwide: major cause of diarrhea. 165 million cases/year (99% in developing countries) 5-15% of all cases of diarrhea, mostly children <4 yrs. 69% of all episodes and 61% of all deaths attributable to shigellosis involved children under 5 years of age canada 2 cases/100,000 estimated 813 cases/year (~4/100,000) 57% travel related and 18% food borne. Least severe, most common developed countries: s. dysenteriae serotype 1 (sd1) severe due to shiga toxin. Most severe, bacillary dysentery ; 20% case fatality rate developing countries: africa, latin america, asia: s. flexneri most common shigella in developing countries; becoming more common in developed countries s. boydii (mostly indian subcontinent) Very similar to e. coli particularly shiga-toxin producing shigella and e. coli have 70-100% dna homology. Survives in neutral ph, resistant to stomach acids. Temperature depends on serotype can survive at 4 c for 21 days in cheese, potato salad and mayonnaise can survive and grow at under 25 c for.
