PSYC 2410 Lecture Notes - Lecture 6: Insomnia, Hypoventilation, Asteroid Family

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Different from gluatamate synthetizing neurons are scattered throughout multiple brain regions. Norepinephrine synthesized from dopamine tin neurons which contain enxyme that allows for conversion. Those neurons found in localized upper vast majority of them are in the pons (metencephalon) Most actions are similar to those of epinephrine share same receptors. Also synthesized and released by post-ganglionic neurons in the sympathetic nervous system. Norepinephrine active throughout the brain projections are widespread ore than those of dopamine. Synthesis not in the brain1 in the medulla of the adrenal glands!! Released in the blood streams, reaches multiple organs. Epinephrine synthesized from norepinephrine, bind to same recepters. Monoamine oxidase inhibitors: formerly use to treat depression; side effects. Side effects: interfere with cardiac function, in a few cases caused sudden death. Beta-blockers (e. g. propranolol): used for anxiety disorders, reduce peripheral aspects of anxiety (sympathetic activation), not anxiety per se (i. e. cns) It increases in cns activity of both dopamine and norepinephrine.

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