PSYC 3030 Lecture Notes - Lecture 6: Voltage-Dependent Calcium Channel, Cyclic Guanosine Monophosphate, Nitric Oxide Synthase

• School: University of Guelph
• Department: Psychology
• Course: PSYC 3030
• Professor: Boyer Winters

Document Summary

Calcium can act like a second messenger, but is not directly involved with g proteins. At resting conditions, the concentration of free cytoplasmic ca2+ is maintained by ca2+ -mg2+ Atpases (calcium pumps) that transport the ion either out of the cell or into the er. Cytoplasmic ca2+ levels can be rapidly elevated by the activation of voltage gated ca2+ channels or ionotropic receptors like an nmda receptor. Ca2+ as a second messenger interacts with intracellular ca2+ binding proteins called calmodulin, to regulate a number of proteins. Cyclic nucleotides: cyclic adenosine monophosphate (camp), cyclic guanosine monophosphate (cgmp) Pde inhibitors: enhance the effect of camp or cgmp by inhibiting their degradation camp and cgmp. Tyrosine and tryptophan hydroxylase, gabaa receptors, neurotransmitter proteins. Photoreceptors, and modulation of camp by stimulating phosphodiesterase. Many voltage gated channels, receptors, catecholamine-synthesizing enzymes, transcription factors. Neurotransmitters alter gene expression by means of mechanisms involving second messengers and transcription factors.