PSYC 4580 Lecture Notes - Lecture 3: Membrane Transport, Cannabinol, Antiemetic
20 Sep 2017
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Cb2 assumed to only be in the immune system: now identified in the cns in microglial cells and are enhanced in the cns, can be detected in pathological brains, not healthy brain. Cb2 agonists may be potential treatments without psychoactive effects. Faah inhibitor increased central levels of anandamide. Magl inhibitor increase central levels of 2-ag. Target approach: aea or 2-ag are only produced when/where needed. Transient receptor potential action channel subfamily v member 1 (trpv1) Activated by capsaicin (hot stuff un chilli pepper) Aea acts as full agonist at trpv1 (2-ag does not) Aea has higher affinity for cb1 than for trpv1. Cbd and cannabigerol (cbg) act as full agonists at trpv1. Oea another fatty acid that trpv1 agonist (no activity n cb1 or cb2) Bioactive lipid lpi acts as an agonist. Cbd acts as antagonist at this receptor. Rimonabant (cb1 antagonist) acts as an agonist at this receptor: but higher concentration required for action at gpr55 than for cb1.
