BGEN 3020 Lecture Notes - Tubulin, Point Mutation, Colchicine

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Types of calcification: dystrophic and metastatic: dystrophic calcification: means abnormal calcification. Serum ca is normal, but damaged tissue becomes calcified. Mcc hypercalcemia (outside of hospital) = primary hyperparathyroidism. Mcc hypercalcemia (inside the hospital) = malignancy induced hypercalcemia. With hypercalcemia, can put ca in normal tissues; this is called metastatic calcification. In dystrophic calcification there is damaged tissue with normal serum ca levels. Metastatic calcification is when there is high ca or phosphorus serum levels (actually when ca is deposited into bone, it is the phosphorus part of solubility product that drives ca into bone). High phosphate levels (very dangerous) will take ca and drive it into normal tissue. Cell membrane defects: rbc membrane defect: spherocytosis is a defect in spectrin within rbc cell membrane; if you can"t see a central area of pallor (if you don"t see a donut) then it"s a spherocyte.