BGEN 3020 Lecture Notes - Glomerulonephritis, Intellectual Disability, Enzyme Assay

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Myeloproliferative dz neoplastic stem cell dz that has lost all regulation and nothing can inhibit it anymore. Polycythemia rubivera: 4 h"s: hyperviscosity (remember pouseau"s law = tpr = viscosity/radius4). So, it is very rare to see an increase in plasma vol with polycythemia, except for this case. Myeloproliferative dz"s take years and years to develop therefore plasma vol is able to keep up; therefore both increase together over time: histaminemia all cells are increased: rbc"s, wbc"s, platelets, including mast cells and basophils. The purines will go into purine metabolism and become uric acid. Example: pt on chemotherapy must also be put on allupurinol to prevent urate nephropathy and prevent renal failure from uric acid. (allupurinol blocks xanthane oxidase). When killing cells you"re releasing millions of purines when the nucleated cells are killed and the tubules are filled with uric acid, leading to renal failure.