BIOL 2420 Lecture Notes - Lecture 11: Renal Function, Macula Densa, Renal Blood Flow

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2420
• Professor: Diana Mlinar

Document Summary

The glomerulus has a positive filtration pressure throughout the entire capillary. Filtration is passive: relies on differences in force to move material across the glomerular membrane. Opposes filtration - more solutes in the blood - water moves in. Opposes filtration - this is out filtrate. Bowman"s capsule colloid osmotic pressure - bc. Opposes filtration - no proteins in the bowman"s capsule. In disease states when proteins leaks into bowman"s capsule this value will increase. If the pressure is ever negative - renal failure. Glomerular filtration rate (gfr) across any capillary is determined by the same three variables: surface area, net filtration pressure, permeability. Filtration rate = filtration coefficient x net filtration pressure. An increases in any of the above variables will increases the gfr. Kf - increase in glomerular surface area occurring when glomerular mesangial cells relax. If mesangial cells relax - the capillary expands - more surface area.