BIOL 2420 Lecture Notes - Lecture 13: Proximal Tubule, Alkalosis, Bile Acid
15 Nov 2016
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Changes in pco2 due to either hypoventilation or hyperventilation affect ph: co2 increases due to hypoventilation. If the ph is disturbed by the respiratory tract then the kidney is responsible for compensation. Ph disturbances that arise from non-respiratory causes. Accumulation of lactic acid: diabetes mellitus. The deprotonated nh3 keto backbones lead to decreased ph: diarrhea. Hco3- is secreted into the small intestine. Alkalosis: excessive vomiting of stomach acid. Use other stores of acid to compensate for the lost of stomach acid: excessive ingestion of antacids. Tums, rolaids - remove acid in stomach. Use other stores of acid to compensate for the lost of stomach acid. When underlying ph disturbances is metabolic both the respiratory and the renal systems can compensate. Under acidotic conditions nearly all of the filtered hco3- is indirectly reabsorbed by cells of the proximal convoluted tubule. The isf and the icf experience increased h concentrations during acidosis: excretion of excess h occurs, via filtration through the glomerulus.
