BIOL 2420 Lecture Notes - Lecture 1: Marathon Trilogy, Kidney Stone Disease, Metabolic Waste

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Humans have a closed cardiovascular system - stable volume and pressure regulated by kidneys. Erythropoietin (epo) -produced in kidneys and promotes red cell production. Deliver supplies to cells far removed from the site of uptake or manufacture. Transport wastes from the cells for elimination elsewhere. Three primary components: (tissue types: blood. Medium for bulk transport of materials: heart. Created hydrostatic pressure gradient - delta p. Osmotic pressure - drives the movement of water into blood through solute concentration. Colloid - oncotic osmotic pressure - high concentration of proteins in circulatory system. Complete septum - separates the two sides of the heart - other mammals have a non- complete septum: vasculature. Closed, dual circuit for the one-way ow of blood. High pressure, high resistance - 120 mmmg. Cyanosis -lack o oxygen in red cells. Complex suspension water, solutes and formed elements. Blood volume is ~ 7-8% of body mass if 1g=1ml. Composed of water (~90%) and a variety of dissolved:

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