BIOL 2420 Lecture Notes - Lecture 29: Pancreatic Lipase Family, Bile Acid, Digestion

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Cck release is triggered by fatty acids in the duodenum. Secretin release is triggered by fatty acids in the duodenum. Bile acids are excreted as conjugated bile salts. Bile acids are necessary for fat digestion in the small intestine. Bile acids are most reabsorbed in the large intestine. Trypsinogen is released - only activated by enterokinase in the bush border. Trypsin in released, can activate itself and others. Cleave individual amino acids off the ends of polypeptides. Unlike carbohydrate digestion, these enzymes are non- speci c. End result is mainly dipeptides, tripeptides and oligopeptides, and a few amino acids. Embedded in the apical membrane are peptidases. Cleave remaining oligopeptides into tripeptides, dipeptides and amino acids. Breakdown remaining di and tripeptides into amino acids. Amino acids, dipeptides, and tripeptides can all be taken up by cotransporters on the apical membrane. Several transporters for groups of amino acids. Coupled with either na+ (single aa) or h+ (di, tri)

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