BIOL 2420 Lecture Notes - Lecture 31: Complement Membrane Attack Complex, Reactive Nitrogen Species, Peroxynitrite
7 Apr 2017
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Document Summary
Inner gut mucus lining, oral cavity and lungs. Ciliated epithelium in the primary bronchus remove microbes and debris from the interior of the lung. 11000 litres of air/day into 3-500 mio. alveoli. Skin = ph 4. 5-6 stomach = ph 1-2. Lysozyme - damage bacterial cell wall of unencapsulated bacteria. Iga antibodies -> disable and clump pathogens. In tears, sweat, saliva, intestinal and bronchial mucus, breast milk. Complement proteins bind to antibodies (igg, igm) Complaint proteins bind directly (dependent on c3b surface presence on pathogen, not accumulated on host cells) to pathogen. A pore in the membrane of the target cell. Na+ and water moves in -> lysis. Larger and more ef cient than neutrophils (take up to 100 bacteria) Present antigens (pieces) to the t-cells, when activated -> very hungry. Very important in the airways of the lung. Remove pathogens, necrotic cellular debris, particles ect. Release of degraded material and agp (antigen presentation)
