BIOL 2520 Lecture Notes - Lecture 15: Vacuole, Enzyme Replacement Therapy, Intellectual Disability

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2520
• Professor: Steven Whyard

Document Summary

Sending the transport vesicles to the correct destination: motor protein will grab vesicle and pull; coats come off. Four steps: movement of the vesicles -on the microtubule component of the cytoskeleton, tethering of vesicles to the target compartment is a specific recognition step. A family of 70 different integral membrane proteins (do(cid:374)(cid:859)t need to remember this number just know it is a large family) each specifying a target. E(cid:454)te(cid:374)ded fi(cid:271)rous protei(cid:374)s (cid:272)alled (cid:862)tetheri(cid:374)g protei(cid:374)s(cid:863: docking - the vesicle membranes become closely aligned. Accomplished by the snare proteins: a family of 35 different proteins, each with different location/target. Little vesicle; rab proteins are brought in by motor proteins; tags proteins that serve as little. Embedded in the golgi; looking to bind to a v-snare these are incorporated in the membrane during budding. The type of v-snare incorporated is determined by the vesicle protein type (type of cop)