ANBI 470.3 Lecture Notes - Lecture 12: White Blood Cell, T Helper Cell, B Cell
20 Jun 2018
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Primary and secondary lymphoid tissue:
Primary
-bone marrow and thymus
-areas of leukocyte production and maturation
Secondary
-lymph nodes, spleen and peyer`s patches
-sites of immune cell localization and activation
odrainage of extracellular fluid to lymph nodes delivers antigens and tissue resident
immune cells
oactivated cells leave lymph nodes enter blood and are delivered to site of infection
ohave a lot of naive T cells and B cells and dendritic cells for antigen presenting cells so
they all can be activated
-naĂŻve T and B cells tend to circulate between lymph nodes via blood (tend to go blood to lymph
nodes and back to blood)
-memory T and B cells tend to circulate from blood to tissues and then drain via ECF to nodes
-memory T and B cells don't tend to migrate to the lymphoid but go out to tissues an this could
be why the response is so rapid
osee the antigen much sooner after the infection process and because they are memory
cells they are activated faster and have a rapid immune response
Specific immunity at mucosal sites
Intestine, lung, reproductive tract
Intestinal peyer`s patches:
-area of dense immune cell localization similar to lymph node
-overlaid by M cells
oM cells: special epithelium, that internalize antigen, bring the antigen across from the
lumen and bring it to the lymphoid / peyers patch
-Induction of IgA type responses
oturn on B cells against antigens and they travel back in to the blood supply and populate
the lamina propria (tissue under GI tract) that secret antibodies that are then released
into the gut
-tolerance versus immunity
odo not want immune response against everything: so somehow by unknown
mechanisms there is decision in the peters patches that choose which ones they want to
have a immune response against
common mucosal immune system
-implications for vaccines
-a B cell activate in the patches, most of the cells go to the gut, some go to the lung, some go to
the report trust, the idea that what makes this a pathogen being unique to the gut, so they send
out B cells to other sites just incase it shoes up there aswel
-gives potential to have nasal and oral vaccines that protect against other parts of the body
(other mucosal sites)
Differentiation of self/non-self
T cell function
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