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Jan 20- Glycolytic Pathway

2 Pages

Biomedical Sciences
Course Code
BMSC 230
Jon Stone

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th Jan 20 /11 Glycolytic Pathway Continued Two non-phosphorylated molecules are glucose and pyruvate Non-phosphorylated molecules can be transported across the membrane Need Phosphorylated Intermediates - Negatively charged and impermeable across membrane o Stay inside cell - Synthesis of ATP o Transfer phosphate group to ADP to produce ATP - Provide proper fit for binding between substrate and enzyme Glucose + 2ADP + 2Pi + 2NAD 2Pyruvate + 2ATP + 2NADH + 4H + 2H2O 1 NADH = 2 ½ ATP 2 NADH = 5 ATP Pathway provides 2 + 5 = 7 ATP If pathway has to operate under standard conditions it cannot proceed because 4 values are positive Pathway may proceed forward under biological conditions Actual free energy change is considered and not standard free energy change - Can have one positive number in actual free energy change Energy starts from a high point and slowly decreases - Shown with actual free energy change graph 2 Pyruvate 2 Acetyl-CoA - Pathway which provides lots of energy Yeast doesn’t have the enzyme to convert pyruvate to lactate - Pyruvate converted to ethanol + CO2 instead - Yeast doesn’t have lactate dehydrogenase Capacity to drink alcohol is directly related to the amount of alcohol dehydrogenase in the liver - More alcohol dehydrogenase = able to consume more alcohol - Alcohol dehydrogenase slowly increases when alcohol consumption is hig
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