MCIM 224 Lecture Notes - Lecture 8: Chromosome, Prodrug, Foscarnet

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Since viruses are not cells (no cytoplasm, ribosomes, they alive? metabolism, etc. 20 - 300 nm ( 10 - 100x smaller than typical bacteria) Dna or rna; single or double stranded. One type of na only (dna or rna, never both) Shell consisting of individual protein subunits ( capsomeres ) surrounding the nucleic acid core. Na core + capsid coat + lipid envelope around the capsid. Viruses have a defined host range (will only infect one type of cell or host) Presence of receptors on host cell to which virus attaches. Presence of suitable metabolic machinery in host cell. Events in the life cycle of a virus. Outside of a host cell, viruses are inert and cannot reproduce. Requires receptors on eucaryotic cell surface to which viral spikes can attach. Spike + receptor interaction partly determines tissue specificity and host range for a virus (only cells carrying the corresponding receptor can be infected)

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