MCIM 309 Lecture Notes - Lecture 3: Dendritic Cell, Immune Complex, Meninges
26 Jan 2017
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Document Summary
Contagion acquisition(day0-1) primary site replication(day1-5) secondary site replication(day5-8) target tissue(day8+) Repsonses non interferon, local and non immunes defence antibody, cell meditaed inflammatory and immunopathogenesis. Disease course prodrome symptoms of disease at primary site healing. Or prodrome symptoms at secondary sites. Cytopathogenesis: failed infection (abortive, cell death (lytic) Inhibit synthesis of dna/mrna or degrade host dna. Virus" (cid:449)ill i(cid:374)hi(cid:271)it sy(cid:374)thesis of (cid:272)ell (cid:373)a(cid:272)ro(cid:373)ole(cid:272)ules or produ(cid:272)e degradatio(cid:374) e(cid:374)zy(cid:373)es. Fusion of neighbouring cells in t cell-cell. Formation allows viral infection to spread from cell-cell. Change in appearance and properties: replication without cell death (persistent) If released gently through exocytosis or through budding. Virus does not want to kill the cell: presence of virus without virus production (latent-recurrent) Cell that restricts/lacks machinery from transcribing viral genes. May need to wait for transcription factors or only growing cells have them. Determinates of viral pathogenesis: access to target tissue, stability of virus in body, ability to cross skin/mucosal membrane, ability to establish viremia, cytopathogenesis.
