MCIM 309 Lecture Notes - Lecture 12: Norovirus, Vomiting, Viral Shedding
25 Feb 2017
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Document Summary
2nd most prevalent cause of common cold. In cytoplasm: basic rna replication, uses rough er and golgi to package. Pathogenesis: causes cytolytic infections, spread by aerosols, longer incubation period, can exacerbate pre-existing pulmonary disease. Sars/mers: outbreaks caused by zoonosis, replicate in epithelial and lymphocytes, significant damage in lung/liver/kidney and liver/git, depletion of immune cells, sars signs. Up to 20% of patients develop diarrhea. Respiratory droplets, sweat and urine: outbreak started in 2002 in south china. Lab diagnosis: not performed other than sars/mers, rt-pcr-from stool/respiratory sampls. Treatment: control is difficult, strict quarantine, screening for fever in travelers, no vaccine yet. Small +rna: vpg and poly a. Pathogenesis: as few as 10 virions will cause infection, small intestine damage, prevents water absorption, vomiting, large number of strains/high mutation rate. Epidemiology: water,shellfish,salad, transmitted fecal/oral route, restsitant to drying and heat, viral shedding by patients. Continue to shed virus for 4 weeks: 100 billion virions/gram of feces. Usually an outbreak (more than 1 person)
