MCIM 309 Lecture Notes - Lecture 11: Serology, Post-Polio Syndrome, Reverse Transcription Polymerase Chain Reaction
25 Feb 2017
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Resistant to ph 3-9, detergents mild sewage treatments and heat: rhino. Liable to acidic ph, optimum growth temp is 33c: hepato, cardio, aphtho. Translated into polyprotein with is then cleaved. Vpg attached to 5" end: packaging genome and initiating viral rna. Enteroviruses: echo, coxsackie, polio, enters via respiratory, replication in oropharynx, primary viremia to target tissue. Without serum antibody to stop primary viremia. Outcomes in unvaccinated people: asymptomatic illness, abortive poliomyelitis, nonparalytic poliomyelitis, paralytic polio. Recoveries in 6 months but can last as long as 2 years: bulbar poliomyelitis. Death in 75: post polio syndrome. May occur 30-40 years later in life. Poliovirus not present but due to loss of neurons. Echovirus: viral meningitis, acute febrile illness, rash may occur, fever rash and coldlike symptoms. Lab diagnosis: csf can be taken, culture can be done (usually fecal/throat, serology. Treatment: pleconaril early in infection, prevention by vaccine. Live or inactivated: better hygiene to prevent spread.
