Class Notes (1,100,000)
CA (620,000)
U of S (3,000)
PHSI (100)
PHSI 208 (100)
Lecture 3

PHSI 208 Lecture Notes - Lecture 3: Peritubular Capillaries, Renal Blood Flow, Afferent Arterioles


Department
Physiology
Course Code
PHSI 208
Professor
Baillie Landon
Lecture
3

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!PHSI!208.6!–!University!of!Saskatchewan!
!Prof:&Landon&Baillie&
!
January'29,'2016'–'Renal'3'
'
X&$'4!04221!3428!:XT@;!'4(&-'(#2$*!#$!'33&-&$(!'$1!&33&-&$(!-&*#*('$%&*5!
Normal!
Increased!afferent!resistance!
Increased!efferent!resistance!
!
!
!
G_33&-&$(!'$1!&33&-&$(!.'/&!
-&*#*('$%&!23!lM>m!!
GC2A&(.&-!82,41!0&!lV>m!
GB/&-'44!-&*#*('$%&!#$%-&'*&*+!
(.&-&32-&!XT@!1&%-&'*&*>!
Ga=!1&%-&'*&*+!`@X!1&%-&'*&*>!
GF&%-&'*&!3428!(2!(.&!A42)&4,4'-!
%'9#44'-#&*!
GB/&-'44!-&*#*('$%&!#$%-&'*&*+!
(.&-&32-&!XT@!1&%-&'*&*>!
GTUC+!04221!#*!&$(&-#$A!(.&!
A42)&-,4,*!'(!(.&!*')&!-'(&!'*!
%2$(-24>!D(^*!$2(!Q,*(!4&'/#$A!'*!
-&'1#4?+!(.&-&32-&!a=!#$%-&'*&*!'$1!
`@X!#$%-&'*&*>!
G"#(&!23!-&*#*('$%&!#*!32,$1!'(!(.&!
&$1!23!(.&!%#-%,#(>!
!
Decreased!afferent!resistance!
Decreased!efferent!resistance!
!
!
!
!
GB/&-'44!-&*#*('$%&!1&%-&'*&*+!
(.&-&32-&!XT@!#$%-&'*&*>!
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Gh2-&!04221!#*!&$(&-#$A!(.&!
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'$1!`@X!#$%-&'*&*>!
GB/&-'44!-&*#*('$%&!1&%-&'*&*+!
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GTUC+!04221!#*!3428#$A!#$(2!(.&!
A42)&-,4,*!'(!(.&!*')&!-'(&+!0,(!
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#$!.?1-2*('(#%!9-&**,-&>!
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!
X&*#*('$%&!#*!)'#$4?!%2$(-244&1!'(!'33&-&$(!'-(&-#24&*>!
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!PHSI!208.6!–!University!of!Saskatchewan!
!Prof:&Landon&Baillie&
!
Normal!
Increased!Afferent!&!Efferent!Resistance!
!
!
Ga-#)'-#4?!'33&-&$(!%2$(-24!/#'!)?2A&$#%!
',(2-&A,4'(#2$!'$1!(,0,42A42)&-,4'-!3&&10'%<>!
GD$%-&'*&1!*?)9'(.&(#%>!
Gb'-A&-!#$%-&'*&!#$!2/&-'44!-&*#*('$%&!-&*,4(*!#$!4'-A&-!
1&%-&'*&!#$!XT@>!
GF&%-&'*&1!a=+!1&%-&'*&1!XT@+!1&%-&'*&1!.?1-2*('(#%!
9-&**,-&+!1&%-&'*&1!A42)&4,4'-!3#4(-'(#2$!-'(&>!
!
Renal!threshold!#*!(.&!94'*)'!%2$%&$(-'(#2$!23!'!*24,(&!8.&$!#(!3#-*(!0&A#$*!(2!'99&'-!#$!(.&!
,-#$&!'(!(.&!92#$(!23!(-'$*92-(!)'E#),)>!T'*#%'44?+!#3!#(!#*!'02/&!(.&!-&$'4!(.-&*.241+!#(*!#$!?2,-!
,-#$&n!
!
Amount&excreted&=&(amount&filtered)&–&(amount&reabsorbed)&+&(amount&secreted)&
&
Glucose&excreted&=&(glucose&filtered)&–&(glucose&reabsorbed)&
&
`4,%2*&!'99&'-#$A!#$!?2,-!,-#$&!#*!<$28$!'*!glycosuria!2-!glucosuria.!C.#*!$2-)'44?!2$4?!2%%,-*!
8#(.!&4&/'(&1!04221!A4,%2*&+!.28&/&-!'!A&$&(#%!1#*2-1&-!(.'(!-&*,4(*!#$!-&1,%&1!(-'$*92-(&-*!#*!
92**#04&>!C.#*!1#*2-1&-!%',*&*!'!),('(#2$!#$!(.&!A&$&!(.'(!*?$(.&*#j&*!A4,%2*&!(-'$*92-(&-*+!'$1!
(.&-&32-&!12&*!$2(!)'<&!&$2,A.>!
!
Peritubular&capillary&pressures&favour&absorption>!b28&-!.?1-2*('(#%!9-&**,-&!#$!9&-#(,0,4'-!
%'9#44'-#&*!-&*,4(*!#$!$&(!-&'0*2-9(#2$!23!#$(&-*(#(#'4!34,#1>&(See&diagram&on&next&page)!
! !
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