BIOL130 Lecture Notes - Lecture 16: Necrosis, Cytoskeleton, Phagocyte
17 Nov 2015
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Biol 130 lecture 16 unit 9 mitosis, meiosis, cell cycle ctd and unit 10 cytoskeleton. How cancer starts: starts as a failure to respect cell cycle checkpoints, especially g1/s checkpoints, with uncontrollable division, dna damage occurs, accumulating more and more mutations, each cancer is unique combo of errors. In a tumour, there are different cell types with different genetic abnormalities. Apoptosis: carried out by caspase family of enzymes, procaspases: caspases present in cell but inactive. Caspase cascade: one molecule of active caspase activates many more that activate others that perform acts such as cleavage of nuclear lamin and cytosolic protein. Triggering of apoptosis by release of cytochrome c: mitochondria are important to apoptosis as the store cytochrome c. Cytoskeleton: fibres that form scaffolding within the cell cytoplasm, static for cell shape, position of organelles, dynamic for movement of organelles and cell components, acts as bones and muscles of the cell. Epithelial cells: model system for studying cytoskeleton.
