BIOL239 Lecture Notes - Lecture 4: Amphiprioninae, Sex Change, Y Chromosome
Set 4: Chromosomes
●Chromosomal theory of inheritance:
oHereditary information is on genes, which are located on chromosomes
oEgg and sperm contribute equally to genetic endowment of offspring through
their nuclei
●Centromere – DNA sequence, on top of which sits a complex of proteins (kinetochore)
●Sex determination
oHumans – presence of Y chromosome = male (e.g. XO is female, but sterile)
oDrosophila
– sex is determined by the ratio of X chromosomes to autosomes
oSex is not determined by X and Y chromosomes in all species, e.g. in some
moths, fertile males are XO, females are XX
oIn other species, sex is determined by environmental factors, e.g.
▪ clown fish (biggest and most dominant as female, all others are male and
the 2nd largest is her mate; if the female dies the second biggest becomes
the male → able to switch sex)
▪in some reptiles (e.g. alligators), sex is determined by temperature of
incubation
chromosomes and reproduction
- Mitosis: nuclear division that results in 2 daughter cells each containing identical
numbers of chromosomes to the parent cell. ⇒ Clones
- Meiosis: nuclear division that results in each egg and sperm containing 1/2 the number of
chromosomes found in other cells (somatic). ⇒ Unique
Drosophila
- phenotypes
Document Summary
Chromosomal theory of inheritance : hereditary information is on genes, which are located on chromosomes, egg and sperm contribute equally to genetic endowment of offspring through their nuclei. Centromere dna sequence, on top of which sits a complex of proteins (kinetochore) Mitosis: nuclear division that results in 2 daughter cells each containing identical numbers of chromosomes to the parent cell. Meiosis: nuclear division that results in each egg and sperm containing 1/2 the number of chromosomes found in other cells (somatic). Drosophila phenotypes female: much larger in size, larger and longer wings, clear cut abs. Male: smaller in size, abs jammed tgt? hook on y chromosomes. Diploid (2 n ), haploid ( n ); n = number of chromosomes in a normal gamete. Karyotype always uses metaphase chromosomes (densed, x shape) Metacentric centromere in middle of chromosome; acrocentric centromere near one end. Trisomy 18 - lethal before or shortly after birth; lots of abnormalities.