BIOL240 Lecture Notes - Lecture 5: Tobacco Mosaic Virus, Enterobacteria Phage T4, Capsomere

• School: University of Waterloo
• Department: Biology
• Course: BIOL240
• Professor: Josh Neufeld

Document Summary

Icosahedral -> 20 faces -> (cid:862)so(cid:272)(cid:272)er (cid:271)all(cid:863) shape (i. e. rhinovirus: built by capsomere subunits forming an icosahedron, thi(cid:374)k of (cid:862)pat(cid:272)hes of a so(cid:272)(cid:272)er (cid:271)all(cid:863, uses lots of cell resources -> why viral infections are bad. Irregular/complex (i. e. t4 bacteriophage: some have an envelope -> plasma membrane around capsid (i. e. hiv, thi(cid:374)k a(cid:374) e(cid:374)(cid:448)elope as (cid:862)(cid:272)lothi(cid:374)g(cid:863, no envelope = naked virus (i. e. poliovirus) Mcleod | rebecca yu: synthesis, host expresses and replicates proteins, assembly, creating more virus particles from proteins, exit, new particles leave cell. Bacteriophage: lytic phage, enter, replicate, cell lysis, temperate phage. Integrate their genome with host genome -> (cid:271)e(cid:272)o(cid:373)es (cid:862)prophage(cid:863: prophage genome replicated with host cell genome (lysogenic phase, stress causes cell lysis (lytic phase, think of a (cid:862)(cid:271)alloo(cid:374)(cid:863) Cultivation: cultivating viruses requires cells, cells -> targets, plaques contain viral particles, cultivating animal viruses requires tissue culture, tissue culture -> targets.