BIOL273 Lecture Notes - Lecture 3: Cardiac Muscle, Smooth Muscle Tissue, Muscle Contraction

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I bands (each sarcomere owns half a i band) Largest known protein: stabilizes position of contractile filaments, elasticity returns stretched muscles to their resting position, helped by nebulin. Inelastic giant protein that lies alongside thin filaments: attaches to z disk, helps align actin filaments of sarcomere. Muscle contraction mechanism: muscle tension force created by contracting muscle, contraction the creation of tension in a muscle. Immune system destroys ach receptros: characterized by skeletal muscle weakness, eserine is used for treatment. Increase levels of pi produced: elevated levels of cytoplasmic pi slow down release of pi from myosin (alters power stroke, decreased calcium release, production of biproducts (calcium phosphate) Larger in diameter than slow twich fibres: fast twitch glycolytic fibers, properties of both oxidative and glycolytic fibers, smaller than fast twitch fibers, combination of oxidative and glycolytic metabolism, more fatigue resistant. Mitochondria myoglobin level color myosin atpase activity contraction duration calcium uptake by sr metabolism resistance to fatigue vascularization diameter.

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