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Lecture 12

Lecture 12 - BIOL308.pdf

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Department
Biology
Course
BIOL 308
Professor
Bruce Wolff
Semester
Fall

Description
Lecture 12The problem with replicating linear moleculesLeading strandis fineContinuous 53 elongationLagging strand when the final RNA fragment is removed from the 5 end of the lagging strand there is no upstream strandno available 3OH onto which DNA Pol I can build to fill the gap3 ends overhandSs unprotectedChromosomes loose about 100 base pairs from their 5 ends in each mitosis Genetic information is getting lost with timeTelomeres and TelomeraseTelomerethe natural end of a linear chromosomeDNA sequence consists of a simple repeating unit 67 nt with a protruded singlestranded 3 end that may fold into a loopHuman sequence is TTAGGGForming a Grich strandTelomeraseenzyme that repairs replicates the ends of chromosomesRibonucleoproteinProteinRNA complexCarries its own little template RNAHasreverse transcriptaseactivity RNADNASummary telomerase is a ribonucleoprotein protein that has RNA polypeptide part and RNA part a ribozyme the RNA performs the action in a protein the Protein carries out actionTelomerase actionrole NOTES FROM LECTURES Page 1
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