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Lecture 12

Lecture 12 - BIOL308.pdf

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BIOL 308
Bruce Wolff

Lecture 12The problem with replicating linear moleculesLeading strandis fineContinuous 53 elongationLagging strand when the final RNA fragment is removed from the 5 end of the lagging strand there is no upstream strandno available 3OH onto which DNA Pol I can build to fill the gap3 ends overhandSs unprotectedChromosomes loose about 100 base pairs from their 5 ends in each mitosis Genetic information is getting lost with timeTelomeres and TelomeraseTelomerethe natural end of a linear chromosomeDNA sequence consists of a simple repeating unit 67 nt with a protruded singlestranded 3 end that may fold into a loopHuman sequence is TTAGGGForming a Grich strandTelomeraseenzyme that repairs replicates the ends of chromosomesRibonucleoproteinProteinRNA complexCarries its own little template RNAHasreverse transcriptaseactivity RNADNASummary telomerase is a ribonucleoprotein protein that has RNA polypeptide part and RNA part a ribozyme the RNA performs the action in a protein the Protein carries out actionTelomerase actionrole NOTES FROM LECTURES Page 1
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