BIOL308 Lecture Notes - Lecture 3: Copolymer, Prentice Hall, Glyoxal
4 Feb 2015
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Homework: watch the movie race for the double helix (1986) (pay attention at terms of use) http://digital. films. com/play/uzsws6. Crick & watson - 3d structure of dna. In early 50-ies they knew: dna structure: base vs. nucleoside vs. nucleotide, chain: phospho-diester bond between phosphate bound to c atom #5 (5") in sugar and oh group at c atom #3 (3") in following sugar, chargaff(cid:2)s rule. A+t is not (necessarily) equal to g+c: x-ray diffraction analysis - dna molecule has regularities in the structure. X-ray diffraction analysis: irradiate crystallized dna with x- rays and capture scatter on photographic film, rosalind franklin & maurice. A form (low water content; almost perfect crystal structure) http://biology200. gsu. edu/houghton/2107%20%2714/lecture24. html. B form (more water trapped in; more difficult to get good images) 3. 4 nm: two chains of the double helix are complementary one to the another (e. g. a to t, atcgta to tagcat) Watson, crick and wilkins: if interested, check: http://www. pbs. org/wgbh/nova/ body/dna-photograph. html.
