BIOL308 Lecture Notes - Lecture 9: Low Fidelity, Recbcd, John Wiley & Sons
4 Feb 2015
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There is an obvious link between presence of telomerase and maintenance of telomere length. (cid:3)aging(cid:4) cells (e. g. , skin) do replicate in absence of telomerase activity consequence: shortening of chromosomes" ends and loss of genetic information, after many generations, descendent cells will inherit defective chromosomes. Such cells will eventually withdraw permanently from cell cycle and stop dividing. Replicative cell senescence : could be a safeguard against uncontrolled cell proliferation, a measuring stick to count cell divisions regulate cell"s lifetime. In other words, in vivo cells lacking functional telomerase did not necessarily stop dividing; some apparently became genetically unstable but continued to divide sometimes into abnormal, cancerous cells more stuff: http://www3. ncbi. nlm. nih. gov:80/entrez/dispomim. cgi?id=187270. Calado r t , and young n s blood 2008;111:4446-4455. Telomeres bound by shelterin protein complex (a) mammalian telomeres consist of tandem repeats of the ttaggg sequence that are bound by the shelterin telosome protein complex. Adjacent to telomeres are the subtelomeric regions, which are also rich in repetitive.
