BIOL308 Lecture Notes - Lecture 18: Mlh1, Nature Reviews Cancer, Gang Of Youths
4 Feb 2015
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1: protection of promoters of active genes from methylation. Cpg islands in promoters of housekeeping genes are preserved as unmethylated genes are active: islands - stretches of 200-500 nucleotides, with gc content (amount of cpg doublets) >50% (different definitions, islands act either as core promoters or upstream elements. Febs letters, volume 583, issue 11, 5 june 2009, pages 1713-1720, cpg islands a rough guide". Robert s. illingworth and adrian p. bird: protection of promoters of active genes from methylation, methyl groups removed through the creation of new strands - which are not methylated at first - this only occurs during. Dna replication: new dna does get methylated later enzyme maintenance methylase, demethylase existence is postulated (active demethylation is happening as well) but the actual enzyme hasn"t been found!!!, biochemical mechanisms implicated in enzymatic dna demethylation: 1. substitution of one h from the methylated cytosine methyl group with. Oh (oxidative demethylation) formation of hydroxymethyl cytosine.
