BIOL354 Lecture Notes - Lecture 7: Hepatic Portal System, Aquatic Toxicology, Bioconcentration
25 Dec 2012
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Review: kow is octanol-water partition coefficient, vessel w/ octanol & water + sample -> centrifuge -> [] Bioaccumulation: net accumulation per organism from all sources. Soil/sediments, and food) is specie specific: bioaccumulation phase: max [toxicant] per tissue increase until a steady state plateau, depurination phase: [toxicant] per tissue decreases through depuration of dna, sharply at first, slows down as the [toxicant] decreases. Bioconcentration: net accumulation per organism from water only. (aquatic toxicology: fish exposed to chemical (constant over time), monitor chemical in tissue until equilibrium, lipophilicity/kow of the contaminant -> bioconcentration @ adipose & liver tissues. Usually the major factor that determines bcf. High kow: partitions preferentially to lipids (e. g. dioxins, pcbs, mehg -> high bcf until bioavailability limited by solubility of the compound) Low kow: partitions preferentially to water (e. g. metals -> low bcf) [toxicant] increases as trophic level increases: toxicant must be able to bioconcentrate & persists within in tissues of the prey.
