BIOL354 Lecture Notes - Superoxide Dismutase, Heat Shock Protein, Enzyme Inhibitor
23 Jun 2014
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Document Summary
Information needed for risk assessment: types of toxicants, toxicant transport and transformation, exposure of target organism, response of target organism. The does makes the poison and the endpoint makes the experiment. Degree of response: lethal: causing death or sufficient to cause death, sublethal: below a level that directly causes death. Timing of the response: acute: a stimulus (contaminant) inducing a rapid response. Life stages is important in sensitivity to toxicants. Life cycle study: lethality, growth, reproduction, development over the entire life cycle of an organism. Critical life stage testing: toxicity at an important life stage (e. g. neonate growth, or reproduction) Early life stage test: sub-set of the critical life stage test, early in development is often the most sensitive test. Weakest link incongruity: when critical life stage used, extrapolation of the environment can be of concern, not all of population will be at this stage, leading to over-estimation of risk.
