CHEM237 Lecture 6: CHEM237-6-Ch6-Proteins-annot.PDF
10 May 2016
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Chapter 6: structures of proteins: general aspects of protein structure: (i) l-amino acids joined by peptide bonds (ii) some residues more frequent than others: 50 - 9,000 aa / polypeptide ( = pp ) average mw of aa 110 da. Mw pp = ~5500 da ~1,000,000 da. 1 pp chain, joined by disulfide bridges and/or non-covalent forces (iv) diversity: many possibilities for any given length i. e. for 200 aa, 20200 possible combinations. Evolution selected only a very small fraction (v) shape: (i. e. 3d structure) is critical for function. Loss of shape results in loss of function. Ch6 p2 of 40 linear sequence of amino acids in polypeptide chain(s) 3d arrangement of atoms in space for single chain. 4 arrangement of 2 or more separate polypeptide chains that comprise the protein. The structural hierarchy in proteins. t e o. Linear (unbranched) sequence of amino acids in polypeptide chain(s) Primary structure of bovine insulin. t e o.
