NE224 Lecture 6: NE224-6-Ch78-Proteins-annotf.PDF
9 Oct 2014
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Chapters 7&8: structures of proteins (i) l-amino acids joined by peptide bonds (ii) some residues more frequent than others: Ala, gly, leu (most common: general aspects of protein structure: 50 - 9,000 aa / polypeptide ( = pp ) average mw of aa 110 da. Mw pp = ~5500 da ~1,000,000 da. 1 pp chain, joined by disulfide bridges and/or non-covalent forces (iv) diversity: many possibilities for any given length i. e. for 200 aa, 20200 possible combinations. Evolution selected only a very small fraction (v) shape: (i. e. 3d structure) is critical for function. Loss of shape results in loss of function. 1 linear sequence of amino acids in polypeptide chain(s) 3d arrangement of atoms in space for single chain. 4 arrangement of 2 or more separate polypeptide chains that comprise the protein. Voetbiochemistry3e 2004 john wiley & sons, inc. figure 7-1the structural hierarchy in proteins. ch7&8 p3 of 40. Linear (unbranched) sequence of amino acids in polypeptide chain(s)
