BIOL 112 Lecture Notes - Lecture 4: Dna Replication, Penicillin, Protein Folding
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BIOL 112 Full Course Notes
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Presence or absence of appropriate enzymes determines the metabolic character of microbes. Bacteria take antibiotics and turn it into diff molecule (resistant to antibiotic) Virulence factor molecule produced by a pathogen which contributes to its pathogenicity. Shape changes to fit substrate-induced fit (tighter binding of substrate to active site. Some break things down, some build (might require atp) them up, others do both. Protein folding brings specific amino acids close to each other to form active site. Those amino acids are often far apart in linear sequence, which is why folding is necessary to bring them together. Active site is highly specific to specific substrates. Binding causes conformational change in the enzyme. Breakdown of glucose into carbon dioxide and water is a spontaneous reaction. (degrade on its own, but takes many, many years. But because of enzymes, our bodies break sugar down in minutes)
