BIOL 201 Lecture Notes - Lecture 12: Organelle, Protein Structure, Benzene
Document Summary
Combined together , both bonding and motional freedom contribute to system stability. Free energy ( g ), enthalpy ( h ), entropy ( s ) sign conventions. H (need less energy to keep bonds together) The entire system of protein folding includes: the peptide the aqueous environment (water) G fold = total difference in stability between unfolded / folded states. H fold = difference in stability associated with differences in bonding. Cb = covalent bonds, ob = other bonds. T s fold = difference in stability associated with differences in molecular motion. Other bonds include non-covalent bonds like ionic bonds, pdpd, idid, etc. Components contributing to g what the contributions look like for the folded state that occurs spontaneously. T s water ________ ( h cb + h ob ) - (t s poly + t s water ) ________
