CAPS 301 Lecture Notes - Winter 2018 Lecture 6 - Dorsal root ganglion, Vascular resistance, Autonomic ganglion
21 Sep 2018
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Presynaptic effects - motor neuron cell body destruction. Paralysis as axon degenerates and nm transmission blocked. Loss of trophic factors released by presynaptic terminal. Muscle atrophy (cell bodies and action potentials are gone from a-mn) Destruction of a-mn axonal myelin impairs ap propagation. Ap slowing results in weakness as motor units fire dis-synchronously. Guillian-barr syndrome: pns disorder; autoimmune attack on schwann cells (myelin degradation) Disrupts exocytosis of ach from nerve terminals. Flaccid paralysis of affected muscles (low motor tone) Myasthenia gravis: most common postsynaptic nmj disorder. Cross-linking of achr"s - internalization of receptor. Reduces ach binding and epp safety factor. Peripheral nerves: composed of bundles of axons. Autonomic = also motor, involved in functions that are not under voluntary control. Acts as nicotinic receptors at the nmj. Spinal nerves: contains axons containing sensory info going in, and axons containing motor info going out. Dorsal root ganglion: where cells bodies of somatic sensory neurons exist.
