CAPS 390 Lecture Notes - Lecture 25: Follicular Cell, Thyroid, Parafollicular Cell
18 Nov 2015
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25lect, endocrine iii, oct 31, 2014; dr. viau. Composed of follicles (follicular epithelial cells surrounding the central, luminal colloid) and parafollicular c cells: follicle cells: produce thyroid hormones (= t3 and t4; a. k. a "thyroxine", parafollicular cells: produce pepide hormone calcitonin. Follicle: stores, synthesizes and releases thyroid hormones (t3/t4). Thyroid hormone synthesis and storage: see figure 13-9 (page 315) Stimulated by tsh from the anterior pituitary which binds to tsh receptors on the basal surface of the follicular epithelial cells. Thyroglobulin (=tgb, not to be confused with thyroxine-binding globulin = tbg = a thyroid hormone carrier protein in the blood) protein synthesis occurs in the rer and it is then modified in both the rer and golgi. Vesicles containing tgb are then transported from the trans golgi network to the apical plasma membrane of the follicular cells, where their contents are exocytosed into the colloid.
