MICB 202 Lecture Notes - Lecture 10: Polio Vaccine, Influenza Vaccine, Vp3
Document Summary
Capsomers: basic subunit of the capsid (asymmetrical structure) Poliovirus organised in the way to make a symmetrical ( icosahedron ) shape. Vp4 is not visible from surface (can"t use antibody against vp4) 180 protein molecules in an immature virus particle. 240 protein molecules in a mature virus particle. Recall: poliovirus are not able to infect mouse cells (permissive but not susceptible: rna virus cell lacks polymerase to read rna as a template. Poliovirus starts off as an infection in the gi tract. Virus recognizes unique sequence on (+) sense rna. cannot function if they package ( ) sense rna. Damage is very fast when motor neurons are infected. You want the igg from the vaccine to protect your motor neurons (they are not replaced). Injected poliovaccine provides igg blood immunity, but no gut immunity (iga). Oral polio vaccine is a live vaccine will infect epithelial cells (causes immune response and secretes.
