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Lecture 10

MICB 202 Lecture Notes - Lecture 10: Polio Vaccine, Influenza Vaccine, Vp3Premium

3 pages67 viewsSummer 2017

Department
Microbiology
Course Code
MICB 202
Professor
Tracy Kion
Lecture
10

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Topic 2: Picornavirus case study (Not active)
Capsomers: basic subunit of the capsid (asymmetrical structure)
Poliovirus
- organised in the way to make a symmetrical (icosahedron) shape
- Immature form: VP0, VP1, VP3
- Mature form: VP1, VP2, VP3, VP4
- VP4 is not visible from surface (can’t use antibody against VP4)
- 60 copies of each protein
- 180 protein molecules in an immature virus particle
- 240 protein molecules in a mature virus particle
Recall: poliovirus are not able to infect mouse cells (permissive but not susceptible)
1. RNA virus – cell lacks polymerase to read RNA as a template
- Encodes gene for an RNA-dependent-RNA-Pol
- Encodes gene for primer (VPg)
Poliovirus starts off as an infection in the GI tract.
Virus recognizes unique sequence on (+) sense RNA.
- cannot function if they package (–) sense RNA
Damage is very fast when motor neurons are infected.
You want the IgG from the vaccine to protect your motor neurons (they are not replaced).
Injected Poliovaccine provides IgG blood immunity, but no gut immunity (IgA).
Oral Polio vaccine is a live vaccine – will infect epithelial cells (causes immune response and secretes
IgA)
Once oral vaccine gets into the host, it starts accumulating mutations and can become virulent again.
Serotype
- a distinct variation within a species of bacteria or virus
- 3 types of poliovirus (PV1, PV2, PV3)
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