PCTH 201 Lecture Notes - Lecture 20: Bioavailability, Barbiturate, Abciximab
22 Nov 2017
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Objectives: learn the different sources of drugs, including natural and non-natural sources, be familiar with examples of drugs derived from each source, understand some of the history behind drug use and drug discovery. Interesting facts: use of drugs is found dating back to 3500 b. c. in the middle east, until the beginning of 20th century, drugs used for the treatment of diseases were obtained from natural sources (e. g. plants) In the last 100 years, there has been an explosive growth in drug discovery: more than half of the world"s population still relies entirely on plants for medicines. Plants seeds, bark, leaves, roots cocaine, morphine, atropine, digoxin, salicin. Minerals earth"s crust, soil, water magnesium, iron, calcium, zinc, gold. Synthetic man-made, generally in the acetaminophen, antihistamines, laboratory barbiturates, sulphonamides. Active ingredients in plants: alkaloids, organic compounds that contain at least one nitrogen atom in a heterocyclic ring, (cid:374)a(cid:373)es usually e(cid:374)d with (cid:862)ine(cid:863)
