PHAR 430 Lecture Notes - Lecture 5: Genetic Variation, Cytochrome P450, Mephenytoin
Document Summary
Among humans in general, the total cyp level in the liver may vary. There is greater variation in the levels of individual cyp enzymes within a population. Select 18 random people and measure their various cyp enzymes in the liver, you get big differences . Reasons for variability: enzyme induction and inhibition, genetic polymorphism, host factors (will go into more detail) Clinical implications: when trying to figure out the t1/2 of a drug, you have to look at a large population in order to get an accurate picture. Results from a single base change or multiple nucleotide base changes in a gene and leads to a variant form of the coded protein. The variant form can have the same, lesser, or greater activity of the wild type, or it might not be expressed at all: the activity of the polymorphic enzyme can differ by.
