PHAR 430 Lecture Notes - Lecture 12: Quinone, Dicoumarol, Thrombocytopenia
Document Summary
Identify the vitamin k-dependent components of the major clotting pathways. Appearance of a disease in cattle caused hemorrhage following minor surgery (cid:862)s(cid:449)eet (cid:272)lo(cid:448)er disease(cid:863) duplicated in rabbits. Lm roderick affected animals lacked the blood clotting factor prothrombin. Karl paul link/harold campbell anticoagulant dicoumarol discovered. Oxidation of coumarin by fungi during spoilage to 4- hydroxycoumarin coupling of 2 4-hydroxycoumarin with formaldehyde produces dicoumarol. Warfarin discovery wisconsin alumni research foundation (warf) Warfarin is then used as a rodenticide (odorless, tasteless, slow acting) (cid:862)super(cid:449)arfari(cid:374)s(cid:863) are (cid:373)ade to (cid:272)o(cid:373)(cid:271)at rode(cid:374)t resista(cid:374)(cid:272)e to (cid:449)arfari(cid:374) Warfarin approved for use in humans (tradename coumadin) Mechanism of action warfarin inhibits coagulation that is dependent on vitamin k. Weakly acidic but coumarin is neutral. Prevents blood loss from damaged blood vessels by producing a platelet/fibrin plug. Vitamin k = a group of fat-soluble organic compounds required for modification and activation of protein cascades required for blood coagulation and metabolism in various tissues (bone)
