PHAR 435 Lecture Notes - Lecture 7: Pregnenolone, Zona Reticularis, Hemiacetal

• School: UBC
• Department: Pharmaceutical Sciences
• Course: PHAR 435
• Professor: Stelvio Bandiera

Document Summary

Identify (by name and location on the steroid molecule) five structural features that are necessary for glucocorticoid activity. Double bond between c4-5, ketone, 2 methyl groups (c18/19), hydroxyl group at c9, side chain that contains a ketone & oh group. Identify (by name, chemical structure, and location on the steroid molecule) two functional groups that increase glucocorticoid activity (relative to mineralocorticoid activity). Identify (by name, chemical structure, and location on the steroid molecule) two functional groups that increase mineralocorticoid activity (relative to glucocorticoid activity). Alpha f at 9 by itself = increased gc, but much more increase in mc; change methyl to aldehyde. Identify (by name, chemical structure, and location on the steroid molecule) functional groups that can be added to an adrenal steroid to enhance the activity of the steroid for i. m. , topical, i. v. , or oral administration. 2nd double bond in a ring; add halogen/methyl group at c6; methyl group at c16; f or halogen at c9 stabilizes oh.