PHRM 211 Lecture Notes - Lecture 8: Glymphatic System, Cerebral Cortex, Memory Consolidation
Document Summary
Sympathetic outflow gradually decreases from nrem to rem. Parasympathetic drives gradually increase from wakefulness to rem sleep. Sensory responsiveness is depressed during sleep (auditory, olfactory, tactile, pain!) If no erection during rem sleep test for impotence. Maturation of the cerebral cortex, oculomotor systems. Rem sleep : learning, memory consolidation, pain suppression, tau/ -amyloid removal (by the glymphatic system) D isorders of i nitiating and m aintaining s leep, e. g. insomnia, sleep apnea, restless legs syndrome. D isorders of s leep s tages and/or partial arousals e. g. rem behavior disorder. An individual perceives that their sleep is inadequate. Very common 40 % of population admit insomnia is a current issue. Examples: exams, bereavement, hospitalization, pain, imminent air travel (novice, infrequent travelers), major earthquakes. Caused by pharmacological therapy (e. g. stimulants - caffeine, depressants - alcohol) Conditioned insomnia the harder one tries, the less they sleep. Sleep apnea patient looks fatigued during the day, but can"t enter sleep.
