PHRM 211 Lecture Notes - Lecture 13: Antipyretic, Analgesic, Paracetamol
Document Summary
Pain is no longer coupled to the presence, intensity, or duration of noxious peripheral stimuli . Instead, central sensitization produces pain hypersensitivity by changing the sensory response elicited by normal inputs , including those that usually evoke innocuous sensations. Combined with opioids and other adjuvants (to limit their doses) Hepatotoxic liver disease, chronic and binge alcohol use (maximum safe dose 2. 6 g. Do not exceed 4 grams daily (avoid otc combination products e. g. cough & cold, No effect on platelet function or stomach lining. Monotherapy for inflammatory conditions (osteoarthritis, rheumatoid arthritis, bursitis, tendonitis, gout, bony pain, low back pain) Allergies asa-sensitive bronchospasm in asthmatics, rashes (sjs, vasculitis) Use lowest dose for shortest amount of time. Avoid ketorolac and diclofenac highest risk of gi bleeds (ketorolac is the worst) All pharmacists must know ratios of opioid strengths e. g. oral morphine to oral hydromorphone is 5:1. Morphine acts as a common currency to compare opioid regimens.
