HLSC 2462U Lecture Notes - Lecture 2: Glycogen Synthase, Cytosol, Lipoprotein
Document Summary
Cellular accumulations (infiltrations: accumulations of material in the cell. Increased rate of production of an endogenous substance(something produced in the body) Insufficient removal (fatty changes in the liver: lack of enzyme endogenous substance (not broken done well enough, defect of proteins (gene mutation) Inhalation of substances, ingestion, infection (heavy metals) (harmful exogenous materials) Accumulation of lipids, insufficient removal of normal substance. Lack of enzyme endogenous substance enzyme could be missing, (oftentimes lysosomal enzymes) Enters the cell (mineral dust, toxins) not fully digestable, accumulates in the cell. Normal substances that accumulate in the cell. Hypoxia reduces production of atp, insufficient o2, Na+ accumulates in the cell, causes cellular swelling. Cns accumulation of lipids in the cns: can lead to tay-sachs disease (progressive damage to cns) Liver, readily available source of energy in cells. Blood glucose levels drop while eating, broken down to increase.
