HLSC 2462U Lecture Notes - Lecture 3: Frameshift Mutation, Acridine Orange, Missense Mutation
Document Summary
If not, the cell will be sent through repair mode . If cell cannot be repaired, goes through apoptosis. Mutagen any substance/agent that can potentially increase frequency of mutations (uv light, nitrogen mustard, viruses) Types of mutations: base pairs substitution and frameshift mutation. Frameshift mutation: insertion/deletion, production of different polypeptide, base pair is either inserted or removed, changes entire reading frame, greatly affects amino acids. Flat, planar molecules that have the ability to insert themselves between nitrogenous bases. Causes a frameshift mutation, causing a shift in nucleotide base pairs. Ex: thymine should be paired to its complementary base, however uv light forces thymine and thymine to come together. Luckily we have an excision repair system extract one of these bases that is a part of this bond and replaced. However, there could be only a 25% chance of getting the correct complementary base since it could choose from (acgt)
