HLSC 2462U Lecture Notes - Lecture 7: Tumor Necrosis Factor Superfamily, Metastasis, Dysplasia
Document Summary
Cancer 1: biology of cancer and tumor spread. Leading cause of death in a developed country. 200 different diseases affiliated with cancer all unique. Accumulations of genetic/epigenetics (switch a gene on or off depending on environmental factors) Don"t think of benign as okay there are instances where it is problematic. Brain has tumour; increases pressure on structures in brain. Slow low mitotic index fast high mitotic index. Looks like tissue of origin might not look like tissue. Mitotic index ratio between number of cells undergoing mitosis and those that are not. Benign look like tissue of origin: tumour of small intestine looks like the cells of small intestine. Metastasize entered into venous or lymphatic system, deposit themselves throughout the body: lungs, bone, brain, etc. Dysplasia abnormal changes n size/shape/number of cells, looks like a mess: when hyperplasia and metaplasia go array, associated with neoplasm growth, can progress but does not indicate cancer.
