HLSC 2463U Lecture Notes - Lecture 9: Hypopituitarism, Hypercalcaemia, Goitre
Document Summary
Dysfunctional gland, tumour, increases or decrease in hormone. Ectopic source from a cell that normally doesn"t secrete that hormone (most likely not an endocrine, doesn"t follow negative feedback loop too much being produced) Increase in hormone metabolism there is less hormone present, decrease there is more hormones. Antibodies changes the response of a certain tissue different response to the hormone. Disorder can lead to increase or decrease in hormonal effects. Not enough blood supply less hormone. Lipophilic not enough plasma protein in serum, less hormone to be transported through the blood. Alterations in the posterior pituitary: inappropriate adh secretion. Released from posterior pituitary goes to blood to kidney binds to receptors, insertion of aquaporins from tubule to the blood for contents to be reabsorbed. Excessive secretion is siadh another source of adh not an endocrine tissue, not within the normal feedback loops. Amount of adh can skyrocket high by ectopic tissue. Water is retained, plasma becomes diluted, hyponatremia, hypoosmolarity.
